CYP11B2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL168295	0.61	19/20
SCHEMBL171635	0.44	18/20
SCHEMBL8506	0.69	16/20
Pyroquilon (SCHEMBL22234)	0.54	15/20
SCHEMBL57346	0.55	14/20
SCHEMBL56634	0.54	14/20
SCHEMBL167581	0.52	14/20
SCHEMBL169511	0.50	14/20
Benzylimidazole (SCHEMBL414)	1.00	13/20
SCHEMBL91856	0.60	13/20
SCHEMBL30985	0.54	13/20
SCHEMBL46315	0.50	13/20
SCHEMBL154263	0.50	13/20
SCHEMBL104710	0.48	13/20
SCHEMBL133949	0.44	13/20
SCHEMBL77025	1.00	12/20
SCHEMBL79024	0.67	12/20
SCHEMBL146559	0.59	12/20
SCHEMBL169054	0.50	12/20
SCHEMBL168806	0.49	12/20

Clinical trials — most relevant to CYP11B2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians	PHASE4	UNKNOWN
The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism	PHASE4	UNKNOWN
The Role of Mineralocorticoid Receptors in Vascular Function	PHASE2/PHASE3	COMPLETED
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)	PHASE3	COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer	PHASE1/PHASE2	COMPLETED
Enoxolone in Major Depression - Biomarker-outcome Relationship	PHASE1/PHASE2	RECRUITING
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer	PHASE2	RECRUITING
Androgen Reduction in Congenital Adrenal Hyperplasia	PHASE2	WITHDRAWN
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma	PHASE2	UNKNOWN
A Trial of Androgen Deprivation, Docetaxel, and Enzalutamide for Metastatic Prostate Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial	PHASE2	NOT_YET_RECRUITING
AMG 386 and Abiraterone for Advanced Prostate Cancer	PHASE2	COMPLETED
Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects	PHASE1	NOT_YET_RECRUITING
A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension	PHASE1	NOT_YET_RECRUITING
A Study to Evaluate the Safety and Drug Levels of ASP5541 in Chinese Participants With Prostate Cancer	PHASE1	RECRUITING
A Study of CYP-001 for the Treatment of Steroid-Resistant Acute Graft Versus Host Disease	PHASE1	COMPLETED
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome	nan	COMPLETED
Connecting Breath and Mind for CYP With Long COVID	nan	UNKNOWN
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas	nan	UNKNOWN
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes	nan	NOT_YET_RECRUITING
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole	nan	WITHDRAWN
68Ga-Pentixafor PET/CT for Guiding Surgical Treatment of Primary Aldosteronism With Bilateral Adrenal Lesions	nan	COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease	nan	COMPLETED
PhaRmacOgenetics and Therapeutic Drug Monitoring In SchizophrEnia	nan	NOT_YET_RECRUITING
Blood Vessel Study	nan	COMPLETED
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
Biological Response to Brief Psychological Challenge	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CYP11B2 binder may also engage these)

Protein	Name	Similarity
CYP11B1	Cytochrome P450 11B1, mitochondrial	1.000	landscape →
Q29527	—	1.000	Q29527 →
P51663	—	0.986	P51663 →
P15150	—	0.980	P15150 →
Q29552	—	0.975	Q29552 →
P30100	—	0.952	P30100 →
Q64658	—	0.945	Q64658 →
P30099	—	0.944	P30099 →
CYP4A11	Cytochrome P450 4A11	0.940	landscape →
P15539	—	0.935	P15539 →
P14580	—	0.931	P14580 →
Q07217	—	0.929	Q07217 →
Q5SUV1	—	0.919	Q5SUV1 →
Q5RJL2	—	0.918	Q5RJL2 →
CYP46A1	Cholesterol 24-hydroxylase	0.916	landscape →
Q9WVK8	—	0.915	Q9WVK8 →
Q8N8L6	—	0.915	Q8N8L6 →
CYP4A22	Cytochrome P450 4A22 (CYPIVA22) (Fatty acid o	0.914	landscape →
P14579	—	0.914	P14579 →
Q86WI3	—	0.913	Q86WI3 →
P10611	—	0.912	P10611 →
A5D7B1	—	0.912	A5D7B1 →
Q86XA0	—	0.912	Q86XA0 →
Q9GJX5	—	0.909	Q9GJX5 →
P57775	—	0.906	P57775 →
Q5VYX0	—	0.906	Q5VYX0 →
A6NKP2	—	0.905	A6NKP2 →
Q9UII6	—	0.905	Q9UII6 →
Q9QXJ4	—	0.904	Q9QXJ4 →
Q8WUG5	—	0.904	Q8WUG5 →