Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.30 |
| ▸ | F2R | P25116 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58036 | 1.00 | TUBB1 (0.45) | TUBB1HPGDKDM4EGAATSHR | |
| SCHEMBL58783 | 0.89 | TUBB1 (0.44) | TUBB1HPGDGAAALOX15SMN1; SMN2 | |
| SCHEMBL88501 | 0.89 | TUBB1 (0.44) | TUBB1HPGDGAAALOX15SMN1; SMN2 | |
| SCHEMBL58451 | 0.89 | TUBB1 (0.56) | TUBB1HPGDKDM4EGAATSHR | |
| SCHEMBL12201945 | 0.88 | TUBB1 (0.52) | TUBB1HPGDGAAHSD17B10ALOX15 | |
| SCHEMBL58787 | 0.88 | TUBB1 (0.52) | TUBB1HPGDGAAHSD17B10ALOX15 | |
| SCHEMBL14592518 | 0.88 | TUBB1 (0.52) | TUBB1HPGDGAAHSD17B10ALOX15 | |
| SCHEMBL14568011 | 0.85 | TUBB1 (0.47) | TUBB1 | |
| SCHEMBL58901 | 0.85 | TUBB1 (0.47) | TUBB1 | |
| SCHEMBL58447 | 0.85 | TUBB1 (0.47) | TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |