Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58783 | 1.00 | TUBB1 (0.44) | TUBB1CTSBGAAHPGDSMN1; SMN2 | |
| SCHEMBL12201945 | 0.89 | TUBB1 (0.52) | TUBB1GAAHPGDSMN1; SMN2ALOX15 | |
| SCHEMBL58787 | 0.89 | TUBB1 (0.52) | TUBB1GAAHPGDSMN1; SMN2ALOX15 | |
| SCHEMBL14592518 | 0.89 | TUBB1 (0.52) | TUBB1GAAHPGDSMN1; SMN2ALOX15 | |
| SCHEMBL58495 | 0.89 | TUBB1 (0.41) | TUBB1GAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL10175741 | 0.89 | TUBB1 (0.45) | TUBB1GAAHPGDSMN1; SMN2ALOX15 | |
| SCHEMBL12201939 | 0.89 | TUBB1 (0.41) | TUBB1GAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL58036 | 0.89 | TUBB1 (0.45) | TUBB1GAAHPGDSMN1; SMN2ALOX15 | |
| SCHEMBL15429790 | 0.87 | TUBB1 (0.44) | TUBB1HPGD | |
| SCHEMBL58501 | 0.87 | TUBB1 (0.44) | TUBB1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |