Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4401590 | 0.83 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1ATM | |
| SCHEMBL10175817 | 0.83 | RAD51 (0.60) | ACSS2SMN1; SMN2ALDH1A1ATMPOLB | |
| SCHEMBL17896760 | 0.83 | CYP11B1 (0.52) | ACSS2SMN1; SMN2ALDH1A1TDP1CA12 | |
| SCHEMBL10249140 | 0.81 | MEN1 (0.66) | MEN1KMT2AACSS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL17896759 | 0.81 | PDE10A (0.57) | ACSS2SMN1; SMN2ALDH1A1ATMTDP1 | |
| SCHEMBL1463084 | 0.81 | KCNH2 (0.58) | PDGFRBPDGFRAALDH1A1TEKPOLB | |
| SCHEMBL460705 | 0.80 | ACSS2 (0.45) | ACSS2SMN1; SMN2ALDH1A1TDP1POLB | |
| SCHEMBL10175815 | 0.80 | CYP11B1 (0.48) | ACSS2SMN1; SMN2ALDH1A1TDP1MAPK14 | |
| SCHEMBL17896717 | 0.79 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2ALDH1A1ATM | |
| SCHEMBL17896623 | 0.79 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |