Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | DDO | Q99489 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14767763 | 0.88 | KDM4E (0.71) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4895906 | 0.82 | KDM4E (0.72) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31570758 | 0.82 | NR4A2 (1.00) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6216675 | 0.82 | NR4A2 (1.00) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30681958 | 0.81 | KDM4E (0.71) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1622313 | 0.81 | KDM4E (0.71) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL26351505 | 0.81 | EGFR (0.61) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5280341 | 0.81 | KDM4E (0.56) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL26349973 | 0.81 | KDM4E (0.71) | NR4A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1622440 | 0.80 | KDM4E (1.00) | NR4A2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3655398-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | Phenex-FXR GmbH (DE) | 2020-05-27 | — | — | EP | disclosed |
| US-20200131144-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | PHENEX-FXR GMBH (DE) | 2020-04-30 | — | — | US | disclosed |
| US-20200131144-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | PHENEX-FXR GMBH (DE) | 2020-04-30 | — | — | US | disclosed |
| CN-110914248-A | LXR modulators containing amines or (thio) amides | 菲尼克斯-FXR股份有限公司 | 2020-03-24 | — | — | CN | disclosed |
| WO-2019016269-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | PHENEX-FXR GMBH (DE) | 2019-01-24 | — | — | WO | disclosed |
| US-20150099781-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-09 | — | — | US | disclosed |
| US-8969342-B2 | Compounds and methods for treating mammalian gastrointestinal microbial infections | BRANDEIS UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| US-20120264760-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120264760-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120101096-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections | University of Georgia Foundation, Inc. (US) | 2012-04-26 | — | — | US | disclosed |
| US-20100022547-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | BRANDEIS UNIVERSITY (US) | 2010-01-28 | — | — | US | disclosed |
| US-20100022547-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | BRANDEIS UNIVERSITY (US) | 2010-01-28 | — | — | US | disclosed |
| WO-2007143557-A2 | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL PARASITIC INFECTIONS | BRANDEIS UNIVERSITY (US) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101096-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections | IMPDH1, IMPDH2, IMPA1 | NR4A2 4041/4885KDM4E 1620/4885ALDH1A1 45/4885 |
| US-20120264760-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | IMPDH1, IMPDH2, ITPA | NR4A2 4470/4885KDM4E 1672/4885ALDH1A1 137/4885 |
| US-20100022547-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | IMPDH1, IMPDH2, ITPA | NR4A2 4470/4885KDM4E 1672/4885ALDH1A1 137/4885 |
| US-20150099781-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections | IMPDH1, IMPDH2, IMPA1 | NR4A2 4041/4885KDM4E 1620/4885ALDH1A1 45/4885 |
| US-20200131144-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | NR1H2, NR1H3, NR1H4 | NR4A2 44/4885KDM4E 2569/4885ALDH1A1 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.