IMPDH2

Inosine-5'-monophosphate dehydrogenase 2 · P12268 · IMPDH2 on Sugi Atlas →

46,437 patent compounds predicted against IMPDH2, 27,110 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Mycophenolic Acid (SCHEMBL4549)	1.00	20/20
Mycophenolate Mofetil (SCHEMBL4195)	0.70	19/20
Mycophenolate Mofetil (SCHEMBL28390)	0.70	19/20
Mycophenolate Mofetil (SCHEMBL218782)	0.70	19/20
Merimepodib (SCHEMBL329922)	1.00	16/20
Merimepodib (SCHEMBL329923)	1.00	16/20
SCHEMBL385582	0.50	15/20
Tiazofurin (SCHEMBL4287)	0.45	14/20
SCHEMBL544506	0.56	8/20
SCHEMBL512594	0.44	8/20
E626 (SCHEMBL5854)	0.76	7/20
E626 (SCHEMBL165027)	0.76	7/20
SCHEMBL263726	0.75	7/20
SCHEMBL184240	0.68	7/20
SCHEMBL188739	0.66	7/20
SCHEMBL188741	0.66	7/20
E626 (SCHEMBL308957)	0.65	7/20
SCHEMBL188740	0.65	7/20
Cytarabine 5'-Phosphate (SCHEMBL249411)	0.62	7/20
E626 (SCHEMBL94794)	0.60	7/20

Clinical trials — most relevant to IMPDH2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)	PHASE4	UNKNOWN
Capecitabine as Second-Line Therapy in Treating Patients With Stage IV Pancreatic Cancer Who Have the Thymidylate Synthase Gene	PHASE2	COMPLETED
GTI-2040 and Capecitabine in Treating Patients With Metastatic Breast Cancer	PHASE2	COMPLETED
Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome	PHASE2	COMPLETED
Mycophenolate Mofetil in Systemic Sclerosis	PHASE1	COMPLETED
IMPase in Treatment-resistant Depression	PHASE1	UNKNOWN
Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines	PHASE1	COMPLETED
Vatalanib and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors	PHASE1	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Bioequivalence of Azathioprine Suspension 10 mg/mL (Jayempi) Versus Azathioprine Tablet 50mg (Imurek®)	PHASE1	COMPLETED
A Phase I Trial of AVN944, an IMPDH Inhibitor, in Adults With Advanced Stage Solid Tumors	nan	WITHDRAWN
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii	nan	ACTIVE_NOT_RECRUITING
Specific Genotypes/Phenotypes of Pneumocystis Jirovecii in Solid Organ Transplant Recipients: Potential Involvement of Mycophenolic Acid	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
The Enzymatic Activity of Lymphocyte Dihydropyrimidine Dehydrogenase DPD in the Blood as a Predictive and Prognostic Factor in Patients With Digestive Cancer in the First or Second Metastatic Line	nan	UNKNOWN
Identification of Patients With High Probability of Poorly Responding to Therapy With Mycophenolic Acid Prodrugs	nan	COMPLETED
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Genetic Variants and Regulation of Specialized Pro-resolving Mediator	nan	RECRUITING
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder	nan	UNKNOWN
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy	nan	RECRUITING
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
A RETROspective Study of Patients With TK2d	nan	COMPLETED
Hydroxymethylation, Incident Type 2 Diabetes and Incident Obesity	nan	UNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Investigation of ADA Enzyme Deficiency	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a IMPDH2 binder may also engage these)

Protein	Name	Similarity
E9PU28	—	1.000	E9PU28 →
Q3SWY3	—	1.000	Q3SWY3 →
P24547	—	1.000	P24547 →
P12269	—	1.000	P12269 →
A0JNA3	—	1.000	A0JNA3 →
Q5RGV1	—	1.000	Q5RGV1 →
O14344	—	1.000	O14344 →
D3ZLZ7	—	1.000	D3ZLZ7 →
B0UXP9	—	1.000	B0UXP9 →
F6S675	—	1.000	F6S675 →
P38697	—	1.000	P38697 →
P50096	—	1.000	P50096 →
IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	1.000	landscape →
Q8F4Q4	—	1.000	Q8F4Q4 →
Q6GMG5	—	1.000	Q6GMG5 →
F7CYY5	—	1.000	F7CYY5 →
P50095	—	1.000	P50095 →
P50094	—	1.000	P50094 →
Q9GZH3	—	1.000	Q9GZH3 →
W6QIT2	—	1.000	W6QIT2 →
Q9L6B7	—	1.000	Q9L6B7 →
P44334	—	1.000	P44334 →
Q4WHZ9	—	1.000	Q4WHZ9 →
Q7SFX7	—	1.000	Q7SFX7 →
P68839	—	1.000	P68839 →
Q59Q46	—	1.000	Q59Q46 →
P0DB88	—	1.000	P0DB88 →
P21620	—	1.000	P21620 →
P0DB89	—	1.000	P0DB89 →
A0A0B5L585	—	0.999	A0A0B5L585 →