Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | DDO | Q99489 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30236806 | 1.00 | HCAR2 (0.55) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12412645 | 0.86 | HCAR2 (0.57) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28283555 | 0.83 | HCAR2 (0.53) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL31032251 | 0.83 | HCAR2 (0.53) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22778668 | 0.80 | HCAR2 (0.50) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL431513 | 0.80 | ATM (0.59) | ALDH1A1KDM4ELMNAPOLBCYP2C9 | |
| SCHEMBL17896592 | 0.80 | CYP11B2 (0.35) | HCAR2LMNACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL31032288 | 0.79 | HCAR2 (0.49) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL30610133 | 0.79 | HCAR2 (0.49) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3942208 | 0.79 | HCAR2 (0.49) | HCAR2ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710430-A | Methods and compounds for restoring mutant p53 function | 皮姆维制药公司 | 2023-09-05 | — | — | CN | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |