Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 5/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | MET | P08581 | 10/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10176246 | 0.97 | FGFR3 (0.51) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10176243 | 0.92 | KDR (0.46) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10177430 | 0.91 | MAP3K7 (0.46) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10176110 | 0.88 | MET (0.54) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10176147 | 0.88 | MAP3K7 (0.43) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10177301 | 0.85 | MAP3K7 (0.46) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10176578 | 0.85 | MAP3K7 (0.46) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10176117 | 0.84 | MAP3K7 (0.46) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL10176389 | 0.83 | FYN (0.45) | FGFR3MAP3K7TAB1KDRMET | |
| SCHEMBL9949743 | 0.82 | FGFR3 (0.71) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165305-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 | INCYTE CORPORATION | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165305-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 | FGFR3, FGFR4, FGFR2 | FGFR3 1/4885MAP3K7 717/4885TAB1 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.