Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442745 | 0.95 | HPGD (0.47) | ROCK1ROCK2STK17AJAK2MAP4K4 | |
| SCHEMBL12811795 | 0.94 | JAK2 (0.52) | ROCK1STK17AJAK2MAP4K4CHEK2 | |
| SCHEMBL12812434 | 0.90 | STK17A (0.51) | STK17ALIMK1ERN1TP53P2RY12 | |
| SCHEMBL1442507 | 0.87 | EGFR (0.50) | ROCK1ROCK2MAP4K4PRKCGPKN2 | |
| SCHEMBL10180104 | 0.85 | HDAC1 (0.51) | ROCK1STK17AJAK2MAP4K4CHEK2 | |
| SCHEMBL1442481 | 0.83 | HPGD (0.53) | ROCK1ROCK2STK17AJAK2MAP4K4 | |
| SCHEMBL1443793 | 0.82 | STK17A (0.48) | STK17AERN1TP53MAPK1LMNA | |
| SCHEMBL12811789 | 0.82 | STK17A (0.49) | STK17ALIMK1TP53P2RY12 | |
| SCHEMBL1442119 | 0.81 | CDK8 (0.47) | ROCK1ROCK2STK17AMAP4K4TP53 | |
| SCHEMBL1443306 | 0.80 | HCRTR1 (0.45) | AURKBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473498-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2012-07-11 | — | — | EP | claimed |