Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | STAMBP | O95630 | 1/20 | 0.45 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180104 | 0.93 | HDAC1 (0.51) | KDM1AHDAC1PSMD14STAMBPCOPS5 | |
| SCHEMBL1442745 | 0.88 | HPGD (0.47) | HPGDJAK2MAP4K4ROS1FLT1 | |
| SCHEMBL12811795 | 0.88 | JAK2 (0.52) | JAK2MAP4K4ROS1FLT1FLT4 | |
| SCHEMBL10179246 | 0.88 | HPGD (0.65) | HPGDJAK2MAP4K4ROS1FLT1 | |
| SCHEMBL1443923 | 0.87 | HPGD (0.67) | HPGDJAK2MAP4K4ROS1FLT1 | |
| SCHEMBL1442696 | 0.86 | ALDH1A1 (0.52) | KDM1AHDAC1JAK2MAP4K4ROCK1 | |
| SCHEMBL10180165 | 0.83 | ROCK1 (0.47) | JAK2MAP4K4ROS1FLT1FLT4 | |
| SCHEMBL1442507 | 0.81 | EGFR (0.50) | MAP4K4ROCK1MAP4K5MAPK1PRKCG | |
| SCHEMBL1442309 | 0.81 | HPGD (0.59) | HPGDERN1 | |
| SCHEMBL10179394 | 0.81 | HPGD (0.59) | HPGDERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | claimed |