Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 8/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | TYK2 | P29597 | 7/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017837 | 0.86 | SYK (0.43) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL1019485 | 0.80 | ULK1 (0.52) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL4302285 | 0.79 | JAK3 (0.57) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL4302281 | 0.79 | JAK3 (0.53) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL1018676 | 0.79 | JAK3 (0.57) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL1018051 | 0.79 | JAK3 (0.52) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL1018107 | 0.78 | JAK3 (0.54) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL12082586 | 0.76 | JAK3 (0.51) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL1018581 | 0.74 | GSK3A (0.52) | JAK3LCKJAK2AURKAAURKB | |
| SCHEMBL29706022 | 0.71 | JAK3 (0.81) | JAK3LCKAURKAKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |