Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963580 | 0.93 | PIK3CD (0.41) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3459095 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3460778 | 0.87 | KDM4E (0.41) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10181157 | 0.84 | KMT2A (0.47) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3460056 | 0.84 | SMN1; SMN2 (0.40) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10180464 | 0.84 | KMT2A (0.47) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3459877 | 0.83 | MAPK8 (0.41) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10181130 | 0.83 | MAPT (0.39) | PIK3CDPIK3R1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10181273 | 0.83 | PIK3CD (0.37) | PIK3CDPIK3R1ALDH1A1CTSLCTSK | |
| SCHEMBL10327330 | 0.83 | SMN1; SMN2 (0.43) | KDM4ESMN1; SMN2ALDH1A1GAAAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |