Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459315 | 0.93 | MAPT (0.43) | MAPK8MAPK9MAPTGAAALDH1A1 | |
| SCHEMBL3460056 | 0.92 | SMN1; SMN2 (0.40) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3461155 | 0.90 | MAPK8 (0.44) | MAPK8MAPK9ALDH1A1MEN1KMT2A | |
| SCHEMBL3459373 | 0.88 | MAPK8 (0.42) | MAPK8MAPK9MAPTGAAALDH1A1 | |
| SCHEMBL3459095 | 0.88 | PIK3CD (0.48) | MAPTGAAALDH1A1RXFP1KDM4E | |
| SCHEMBL3460778 | 0.87 | KDM4E (0.41) | MAPTGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10180401 | 0.86 | RXFP1 (0.44) | MAPTGAAALDH1A1KMT2ARXFP1 | |
| SCHEMBL3460054 | 0.85 | SMN1; SMN2 (0.44) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10181157 | 0.85 | KMT2A (0.47) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10180464 | 0.85 | KMT2A (0.47) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |