Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 7/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | STAT3 | P40763 | 12/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3062620 | 0.99 | PRKAA2 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3047165 | 0.92 | STAT3 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| SCHEMBL3059301 | 0.92 | STAT3 (0.52) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| SCHEMBL3067020 | 0.91 | STAT3 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3056431 | 0.91 | STAT3 (0.47) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3055979 | 0.90 | PRKAA2 (0.45) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3058139 | 0.90 | STAT3 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| SCHEMBL3055561 | 0.88 | PRKAA2 (0.43) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3062626 | 0.86 | PIK3CA (0.38) | PRKAA2PIK3CASTAT3MLNR | |
| Bromide SCHEMBL3065308 | 0.86 | STAT3 (0.59) | STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551999-B2 | Heterocyclic compound and pharmaceutical composition thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | claimed |
| EP-2207773-B1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMA CO LTD (JP) | 2012-07-11 | — | — | EP | claimed |