Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 7/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | STAT3 | P40763 | 11/20 | 0.43 |
| ▸ | MLNR | O43193 | 2/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3066371 | 0.93 | PRKAA2 (0.46) | PRKAA2PIK3CASTAT3MLNRPRKAB2 | |
| Bromide SCHEMBL3056431 | 0.92 | STAT3 (0.47) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3058139 | 0.91 | STAT3 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3062620 | 0.91 | PRKAA2 (0.46) | PRKAA2PIK3CASTAT3MLNRPRKAB2 | |
| SCHEMBL3059301 | 0.91 | STAT3 (0.52) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| SCHEMBL10181013 | 0.90 | PRKAA2 (0.46) | PRKAA2PIK3CASTAT3MLNRPRKAB2 | |
| Bromide SCHEMBL3047165 | 0.90 | STAT3 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| SCHEMBL3067020 | 0.89 | STAT3 (0.46) | PRKAA2PIK3CASTAT3PRKAB2PRKAG1 | |
| Bromide SCHEMBL3063862 | 0.88 | STAT3 (0.53) | PRKAA2PIK3CASTAT3MLNR | |
| Bromide SCHEMBL3057059 | 0.87 | PRKAA2 (0.46) | PRKAA2PIK3CASTAT3MLNRPRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551999-B2 | Heterocyclic compound and pharmaceutical composition thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2207773-B1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMA CO LTD (JP) | 2012-07-11 | — | — | EP | disclosed |
| US-20100261720-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261720-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | COL1A1, COL2A1, COL14A1 | PRKAA2 4297/4885PIK3CA 3582/4885STAT3 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.