Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 9/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3747382 | 0.92 | KMT2A (0.50) | SMN1; SMN2RAB9AKMT2AALDH1A1NPC1 | |
| SCHEMBL13012512 | 0.92 | KMT2A (0.50) | SMN1; SMN2RAB9AKMT2AALDH1A1NPC1 | |
| SCHEMBL3744821 | 0.80 | CA2 (0.43) | KMT2ALMNACA2CA1CA12 | |
| SCHEMBL3744814 | 0.80 | CA2 (0.43) | KMT2ALMNACA2CA1CA12 | |
| SCHEMBL3737687 | 0.80 | CA2 (0.46) | KMT2ALMNACA2CA1CA12 | |
| SCHEMBL3737690 | 0.80 | CA2 (0.46) | KMT2ALMNACA2CA1CA12 | |
| SCHEMBL3733439 | 0.78 | CA2 (0.45) | KMT2ALMNACA2CA1CA12 | |
| SCHEMBL3733436 | 0.78 | CA2 (0.45) | KMT2ALMNACA2CA1CA12 | |
| SCHEMBL13012651 | 0.77 | CA2 (0.46) | SMN1; SMN2KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL3746412 | 0.77 | CA2 (0.47) | KMT2ALMNAMAPTCA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468734-A1 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry | Siemens Medical Solutions USA, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |