CA2

Carbonic anhydrase 2 · P00918 · CA2 on Sugi Atlas →

1,415,191 patent compounds predicted against CA2, 737,976 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Benzenesulfonamide (SCHEMBL729)	1.00	18/20
Sulfanilamide (SCHEMBL740)	1.00	17/20
Busulfan (SCHEMBL4373)	0.50	16/20
Improsulfan (SCHEMBL8954)	0.35	16/20
Benzoic Acid (SCHEMBL823)	1.00	15/20
SCHEMBL3354	0.67	15/20
Edetic Acid (SCHEMBL1373)	0.40	15/20
Edetic Acid (SCHEMBL905)	0.39	15/20
SCHEMBL7369	0.56	13/20
SCHEMBL8588	0.48	13/20
Phenylmethanesulfonamide (SCHEMBL7371)	1.00	12/20
P-Toluenesulfonamide (SCHEMBL7370)	1.00	11/20
SCHEMBL9577	0.64	10/20
SCHEMBL3353	0.61	10/20
Sodium Lauryl Sulfate (SCHEMBL1102)	0.59	10/20
SCHEMBL7434	0.53	10/20
SCHEMBL7410	0.42	10/20
SCHEMBL6230	0.53	9/20
Methylparaben (SCHEMBL4440)	1.00	8/20
SCHEMBL9578	0.61	7/20

Clinical trials — most relevant to CA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis	PHASE4	COMPLETED
Chronic Clinical Effect of Acetazolamide	PHASE2/PHASE3	COMPLETED
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m	PHASE3	COMPLETED
A Study of the Safety and Efficacy of rhGAA in Patients With Infantile-onset Pompe Disease	PHASE2/PHASE3	COMPLETED
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis	PHASE1/PHASE2	COMPLETED
A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients	PHASE1/PHASE2	COMPLETED
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Studying Physiological and Anatomical Cerebral Effects of Carbon Dioxide and Tilt	PHASE1	COMPLETED
Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma	EARLY_PHASE1	RECRUITING
Multicenter Study of 18F-Labeled NY104 for PET/CT Imaging in Renal Cell Carcinoma	nan	RECRUITING
Incidence of Renal Tubular Acidosis in Nephrology Unit in Assiut University Childern Hospital	nan	UNKNOWN
Calciotropic Effects After HCG Stimulation Test	nan	COMPLETED
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury	nan	COMPLETED
Studying Tumor Tissue Samples From Patients Who Have Undergone Surgery for Localized Kidney Cancer	nan	WITHDRAWN
The Etiology and Progression of Brain Tumors	nan	COMPLETED
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential	nan	NOT_YET_RECRUITING
Clinical Assessment of Low Calcium In traUMa (CALCIUM)	nan	ACTIVE_NOT_RECRUITING
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19	nan	UNKNOWN
Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines	nan	UNKNOWN
Improving Safety in Pediatric Thyroidectomy by PTH Measurements	nan	COMPLETED
The Effect of Cinacalcet on Gastric Acid Output in Healthy Subjects	nan	COMPLETED
The Incidence of Hypocalcemia in Pregnant Women at Siriraj Hospital	nan	UNKNOWN
Efficacy of Potassium Citrate in the Treatment of Postmenopausal Osteopenia	nan	COMPLETED
Carnosine Supplementation on Quantity/Quality of Oral Salivae.	nan	UNKNOWN
Serum and Cellular Biomarkers for Aortic Valve Stenosis	nan	UNKNOWN
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells	nan	COMPLETED
Study of the Crystallization Inhibition Capacity of the Uric Acid in Urine in a Group of Lithiasic Patients After Intake of a Food Supplement	nan	COMPLETED
COMPARISON OF THE EFFICACY BETWEEN PREOPERATIVE CALCIUM & VITAMIN D3 VERSUS CALCIUM SUPPLEMENTATION ALONE TO PREVENT POST OPERATIVE SYMPTOMATIC HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY IN EUTHYROID PATIENTS	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a CA2 binder may also engage these)

Protein	Name	Similarity
P00921	—	1.000	P00921 →
P27139	—	0.997	P27139 →
P07630	—	0.995	P07630 →
CA3	Carbonic anhydrase 3	0.995	landscape →
Q8HY33	—	0.994	Q8HY33 →
Q8UWA5	—	0.994	Q8UWA5 →
Q92051	—	0.994	Q92051 →
P00920	—	0.993	P00920 →
P00919	—	0.993	P00919 →
P00916	—	0.993	P00916 →
P48282	—	0.992	P48282 →
P00922	—	0.992	P00922 →
Q1LZA1	—	0.991	Q1LZA1 →
P07452	—	0.990	P07452 →
P35217	—	0.990	P35217 →
P13634	—	0.989	P13634 →
CA13	Carbonic anhydrase 13	0.989	landscape →
Q9D6N1	—	0.989	Q9D6N1 →
Q7M316	—	0.987	Q7M316 →
P07450	—	0.987	P07450 →
P00917	—	0.987	P00917 →
P83299	—	0.987	P83299 →
Q7M317	—	0.986	Q7M317 →
CA1	Carbonic anhydrase 1	0.986	landscape →
B0BNN3	—	0.985	B0BNN3 →
Q3SZX4	—	0.985	Q3SZX4 →
CA7	Carbonic anhydrase 7	0.984	landscape →
Q5S1S4	—	0.982	Q5S1S4 →
Q9ERQ8	—	0.981	Q9ERQ8 →
P16015	—	0.981	P16015 →