Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.64 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.63 |
| ▸ | OSBP | P22059 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | RORC | P51449 | 1/20 | 0.59 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.59 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | UGCG | Q16739 | 2/20 | 0.53 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334979 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL26032459 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL17236066 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL2334975 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL17665325 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL15826833 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL15702070 | 0.97 | POLA1 (0.64) | POLA1CYP46A1OSBPUSP2LMNA | |
| Hydrochloric Acid SCHEMBL2403220 | 0.96 | POLA1 (0.63) | POLA1CYP46A1OSBPUSP2LMNA | |
| Hydrochloric Acid SCHEMBL2403217 | 0.96 | POLA1 (0.63) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL26032465 | 0.96 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174459-A1 | LIPID CONTAINING FORMULATIONS | ARBUTUS BIOPHARMA CORPORATION (US) | 2023-06-08 | — | — | US | disclosed |
| US-20180065918-A1 | LIPID CONTAINING FORMULATIONS | ARBUTUS BIOPHARMA CORPORATION (CA) | 2018-03-08 | — | — | US | disclosed |
| US-9663449-B2 | — | — | 2017-05-30 | — | — | US | disclosed |
| US-20140121393-A1 | LIPID CONTAINING FORMULATIONS | TEKMIRA PHARMACEUTICALS CORPORATION (CA) | 2014-05-01 | — | — | US | disclosed |
| US-8642076-B2 | Lipid containing formulations | TEKMIRA PHARMACEUTICALS CORPORATION | 2014-02-04 | — | — | US | disclosed |
| US-20120046478-A1 | LIPID CONTAINING FORMULATIONS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-8034376-B2 | Lipid containing formulations | Alnylam Pharamaceticals, Inc. (US) | 2011-10-11 | — | — | US | disclosed |
| US-20090023673-A1 | LIPID CONTAINING FORMULATIONS | BANK OF AMERICA, N.A. | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065918-A1 | LIPID CONTAINING FORMULATIONS | LIPA, POLRMT, PHOSPHO1 | POLA1 318/4885CYP46A1 640/4885OSBP 370/4885 |
| US-20230174459-A1 | LIPID CONTAINING FORMULATIONS | LIPA, POLRMT, PHOSPHO1 | POLA1 318/4885CYP46A1 640/4885OSBP 370/4885 |
| US-20140121393-A1 | LIPID CONTAINING FORMULATIONS | LIPA, POLRMT, PHOSPHO1 | POLA1 318/4885CYP46A1 640/4885OSBP 370/4885 |
| US-20090023673-A1 | LIPID CONTAINING FORMULATIONS | LIPA, POLRMT, PHOSPHO1 | POLA1 318/4885CYP46A1 640/4885OSBP 370/4885 |
| US-20120046478-A1 | LIPID CONTAINING FORMULATIONS | LIPA, POLRMT, PHOSPHO1 | POLA1 318/4885CYP46A1 640/4885OSBP 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.