POLRMT — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16698822	1.00	1/20
SCHEMBL16698824	1.00	1/20
SCHEMBL19778887	1.00	1/20
SCHEMBL16699054	0.85	1/20
SCHEMBL16699057	0.85	1/20
SCHEMBL19779220	0.85	1/20
SCHEMBL16708570	0.82	1/20
SCHEMBL16710440	0.82	1/20
SCHEMBL20960037	0.79	1/20
SCHEMBL20756290	0.73	1/20
SCHEMBL20755989	0.72	1/20
SCHEMBL16699074	0.71	1/20
SCHEMBL16699077	0.71	1/20
SCHEMBL23827914	0.70	1/20
SCHEMBL16708556	0.70	1/20
SCHEMBL16708507	0.69	1/20
SCHEMBL20960075	0.69	1/20
SCHEMBL16708504	0.68	1/20
SCHEMBL19778886	0.68	1/20
SCHEMBL24942272	0.67	1/20

Clinical trials — most relevant to POLRMT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
PREventing Progression of Adipose Tissue Redistribution	PHASE4	COMPLETED
KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases	PHASE3	RECRUITING
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)	PHASE3	COMPLETED
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)	PHASE1/PHASE2	COMPLETED
OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)	PHASE2	COMPLETED
The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease	PHASE2	UNKNOWN
Choroid Plexus Dysfunction in Neurological Diseases	nan	RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Genetic Diagnosis in Inborn Errors of Metabolism	nan	ENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Mitochondrial nt3243 A>G Mutation in Taiwan	nan	UNKNOWN
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Randomised Controlled Trial of an Antioxidant and Sunscreen Combination Cream for Reducing DNA Damage in Human Skin	nan	COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
Natural History Study of Mitochondrial Myopathy	nan	RECRUITING
Collection of Samples of Bone Marrow Aspiration From Patients With Myelodysplastic Syndrome	nan	ACTIVE_NOT_RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a POLRMT binder may also engage these)

Protein	Name	Similarity
Q8BKF1	—	1.000	Q8BKF1 →
Q4R5Q4	—	0.983	Q4R5Q4 →
Q9BQ95	—	0.982	Q9BQ95 →
Q8VDP3	—	0.981	Q8VDP3 →
O75064	—	0.981	O75064 →
Q3T1I9	—	0.981	Q3T1I9 →
A0JN53	—	0.980	A0JN53 →
Q66H85	—	0.980	Q66H85 →
ERN2	Serine/threonine-protein kinase/endoribonuclease IRE2	0.979	landscape →
Q8TDZ2	—	0.979	Q8TDZ2 →
Q91ZJ0	—	0.979	Q91ZJ0 →
Q99MQ3	—	0.979	Q99MQ3 →
Q8BIW9	—	0.979	Q8BIW9 →
Q68DD2	—	0.978	Q68DD2 →
D3ZBP4	—	0.978	D3ZBP4 →
Q9Z2E3	—	0.978	Q9Z2E3 →
Q8CIE4	—	0.978	Q8CIE4 →
TELO2	Telomere length regulation protein TEL2 homolog	0.978	landscape →
ENGASE	Cytosolic endo-beta-N-acetylglucosaminidase	0.978	landscape →
Q2KHV9	—	0.978	Q2KHV9 →
E9QAM5	—	0.978	E9QAM5 →
Q3SX05	—	0.978	Q3SX05 →
Q8WVB6	—	0.978	Q8WVB6 →
Q9H6W3	—	0.978	Q9H6W3 →
Q9BYK8	—	0.977	Q9BYK8 →
Q56A04	—	0.977	Q56A04 →
Q1JQC5	—	0.977	Q1JQC5 →
Q58CQ5	—	0.977	Q58CQ5 →
Q924T7	—	0.977	Q924T7 →
P54777	—	0.977	P54777 →