Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10182402 | 0.85 | CHRNB4 (0.39) | SMN1; SMN2LRRK2MAPT | |
| SCHEMBL569768 | 0.78 | MEN1 (0.49) | NPC1RAB9AKDM4ESMN1; SMN2CFTR | |
| SCHEMBL10083554 | 0.73 | KMT2A (0.44) | LRRK2ALDH1A1KMT2AMAPTHSD17B10 | |
| SCHEMBL569321 | 0.72 | MEN1 (0.68) | NPC1RAB9AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL10182349 | 0.72 | CFTR (0.43) | NPC1RAB9AKDM4ESMN1; SMN2CFTR | |
| SCHEMBL10182704 | 0.71 | CHRNB4 (0.39) | SMN1; SMN2LRRK2 | |
| SCHEMBL570393 | 0.71 | DRD2 (0.47) | NPC1RAB9AKDM4ESMN1; SMN2GRM4 | |
| SCHEMBL10182208 | 0.71 | CFTR (0.51) | NPC1RAB9AKDM4ESMN1; SMN2CFTR | |
| SCHEMBL10182336 | 0.71 | TP53 (0.58) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL570223 | 0.71 | CHRNB4 (0.42) | SMN1; SMN2LRRK2ALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012017021-A2 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY | GRAFFINITY PHARMACEUTICALS GMBH (DE) | 2012-02-09 | — | — | WO | disclosed |