DRD2

D(2) dopamine receptor · P14416 · DRD2 on Sugi Atlas →

758,281 patent compounds predicted against DRD2, 426,302 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL8078	1.00	20/20
Aripiprazole (SCHEMBL8255)	1.00	20/20
Aripiprazole (SCHEMBL8044)	0.98	20/20
SCHEMBL8423	1.00	18/20
SCHEMBL7929	0.93	17/20
Ropinirole (SCHEMBL35212)	1.00	15/20
Haloperidol (SCHEMBL8264)	1.00	14/20
Risperidone (SCHEMBL27911)	1.00	14/20
Moperone (SCHEMBL34340)	1.00	14/20
Trazodone (SCHEMBL28167)	1.00	12/20
Ziprasidone (SCHEMBL28028)	1.00	11/20
SCHEMBL6700	0.53	11/20
Clozapine (SCHEMBL8397)	1.00	10/20
SCHEMBL33323	0.51	10/20
Bepotastine (SCHEMBL29459)	0.51	10/20
Prochlorperazine (SCHEMBL18429)	1.00	9/20
Amisulpride (SCHEMBL34126)	1.00	9/20
Fenoldopam (SCHEMBL34250)	1.00	9/20
SCHEMBL8511	1.00	8/20
Amoxapine (SCHEMBL33950)	1.00	8/20

Clinical trials — most relevant to DRD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Identify Peripheral Biomarkers of Symptomatology, Neurocognitive Functions, and Medication Response in ADHD	PHASE4	UNKNOWN
Adjunct Treatment With Cariprazine for Adults With Attention-deficit/Hyperactivity Disorder	PHASE4	UNKNOWN
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)	PHASE4	COMPLETED
Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease	PHASE4	COMPLETED
A New Pharmacotherapy for Alcohol Dependence: Olanzapine	PHASE3	COMPLETED
New Treatment for Alcohol and Nicotine Dependence	PHASE2/PHASE3	COMPLETED
Examination of Bromocriptine on Homeostatic and Hedonic Mechanisms of Food Intake in Individuals at High Risk for T2DM	PHASE3	COMPLETED
D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement	PHASE2	COMPLETED
Psychopharmacology for Cocaine Dependence - Buspirone	PHASE2	COMPLETED
Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence (ALC-DRD2-APO)	PHASE2	UNKNOWN
Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET	PHASE1/PHASE2	COMPLETED
Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112	PHASE1	COMPLETED
PET Imaging and Bariatric Surgery	PHASE1	COMPLETED
Brain Dopaminergic Signaling in Opioid Use Disorders	EARLY_PHASE1	COMPLETED
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography	nan	COMPLETED
A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.	nan	UNKNOWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
A Combined Psycho-pharmacological and Brain Imaging Study of Human Sexuality	nan	SUSPENDED
Dopamine and Insulin Resistance	nan	COMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios	nan	COMPLETED
Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia	nan	COMPLETED
The Genetic Basis for Vulnerability to Substance Abuse	nan	COMPLETED
Attention Deficit Hyperactivity Disorder: Nutrition and Environment	nan	UNKNOWN
The Effects of Pharmacotherapy on Brain Mechanisms Underlying Cocaine Dependence.	nan	SUSPENDED
A Positional Cloning Study on Schizophrenia	nan	COMPLETED
Dopamine Receptor Imaging in Mood Disorders	nan	COMPLETED
Tetrabenazine for Partial Responders	nan	COMPLETED
A Nutritional Intervention for Diabetic Neuropathy	nan	COMPLETED
A Nutritional Intervention for Diabetic Neuropathy (WCCR-DN2)	nan	COMPLETED
Human Adaptation to High Altitude	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DRD2 binder may also engage these)

Protein	Name	Similarity
P60026	—	1.000	P60026 →
P52702	—	1.000	P52702 →
Q6TLI9	—	1.000	Q6TLI9 →
Q9GJU1	—	1.000	Q9GJU1 →
P20288	—	1.000	P20288 →
P61169	—	1.000	P61169 →
P61168	—	1.000	P61168 →
O73810	—	1.000	O73810 →
DRD1	D(1A) dopamine receptor	1.000	landscape →
O42384	—	1.000	O42384 →
P18901	—	1.000	P18901 →
Q16950	—	0.999	Q16950 →
P53453	—	0.999	P53453 →
Q25322	—	0.999	Q25322 →
Q19084	—	0.999	Q19084 →
Q91081	—	0.999	Q91081 →
O42385	—	0.999	O42385 →
O02213	—	0.999	O02213 →
Q95136	—	0.998	Q95136 →
P24628	—	0.998	P24628 →
P42288	—	0.998	P42288 →
P50130	—	0.997	P50130 →
Q6XXX9	—	0.997	Q6XXX9 →
Q25321	—	0.997	Q25321 →
P31390	—	0.996	P31390 →
O70528	—	0.996	O70528 →
Q2KNE5	—	0.996	Q2KNE5 →
Q18775	—	0.996	Q18775 →
Q6XXY0	—	0.996	Q6XXY0 →
O77680	—	0.995	O77680 →