Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.51 |
| ▸ | TACR2 | P21452 | 1/20 | 0.49 |
| ▸ | TSG101 | Q99816 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15591315 | 1.00 | PRMT5 (0.51) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL10167164 | 0.96 | TACR2 (0.53) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL15099968 | 0.96 | PRMT5 (0.50) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL13779892 | 0.95 | TACR2 (0.47) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL13492856 | 0.95 | PRMT5 (0.48) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL15088335 | 0.93 | PRMT5 (0.48) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL18595987 | 0.91 | PRMT5 (0.49) | PRMT5WDR77TACR2TSG101 | |
| SCHEMBL12837921 | 0.90 | MDM2 (0.42) | PRMT5WDR77TACR2TSG101MEN1 | |
| SCHEMBL14144739 | 0.77 | ALB (0.51) | TACR2 | |
| SCHEMBL15489018 | 0.72 | ALB (0.49) | TACR2TSG101MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980837-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-1778718-B1 | INHIBITORS OF IAP | GENENTECH INC (US) | 2014-10-08 | — | — | EP | disclosed |
| US-8835393-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120270886-A1 | INHIBITORS OF IAP | KOEHLER MICHAEL F T (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20120202750-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090221630-A1 | IAP INHIBITORS | GENENTECH, INC. | 2009-09-03 | — | — | US | disclosed |
| US-20090221630-A1 | IAP INHIBITORS | GENENTECH, INC. | 2009-09-03 | — | — | US | disclosed |
| US-20080146808-A1 | AZABICYCLO-OCTANE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146808-A1 | AZABICYCLO-OCTANE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-7345081-B2 | Azabicyclo-octane inhibitors of IAP | GENENTECH, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| WO-2007106192-A2 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221630-A1 | IAP INHIBITORS | XIAP, BIRC5, BIRC3 | PRMT5 1073/4885WDR77 1105/4885TACR2 4059/4885 |
| US-20080146808-A1 | AZABICYCLO-OCTANE INHIBITORS OF IAP | XIAP, BIRC3, BIRC2 | PRMT5 1622/4885WDR77 1397/4885TACR2 667/4885 |
| US-20070299052-A1 | Inhibitors of IAP | XIAP, BIRC5, BIRC3 | PRMT5 1021/4885WDR77 715/4885TACR2 4224/4885 |
| US-20120202750-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | PRMT5 1021/4885WDR77 715/4885TACR2 4224/4885 |
| US-20120270886-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | PRMT5 934/4885WDR77 905/4885TACR2 4378/4885 |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | PRMT5 407/4885WDR77 622/4885TACR2 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.