SCHEMBL15099968

CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)C(=O)N[C@@H](C)C(N)=O)C(c1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	7/20	0.50

▸	WDR77	Q9BQA1	7/20	0.50

▸	TACR2	P21452	1/20	0.48

▸	TSG101	Q99816	11/20	0.47

▸	MEN1	O00255	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL15591315	0.96	PRMT5 (0.51)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL10182947	0.96	PRMT5 (0.51)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL10167164	0.96	TACR2 (0.53)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL15088335	0.95	PRMT5 (0.48)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL18595987	0.94	PRMT5 (0.49)	PRMT5WDR77TACR2TSG101
SCHEMBL13779892	0.92	TACR2 (0.47)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL13492856	0.91	PRMT5 (0.48)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL12837921	0.86	MDM2 (0.42)	PRMT5WDR77TACR2TSG101MEN1
SCHEMBL15489018	0.73	ALB (0.49)	TACR2TSG101MEN1
SCHEMBL14144739	0.72	ALB (0.51)	TACR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2013103703-A1	INHIBITORS OF IAP	CURIS, INC. (US)	2013-07-11	—	—	WO	disclosed