Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 16/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018307 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1GFERKMT2AHTR6 | |
| SCHEMBL1012769 | 0.91 | PDE4B (0.47) | SMN1; SMN2MEN1GFERKMT2AHTR6 | |
| SCHEMBL1012768 | 0.91 | PDE4B (0.47) | SMN1; SMN2MEN1GFERKMT2AHTR6 | |
| SCHEMBL1012906 | 0.81 | PDE4B (0.47) | HTR6DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL1012808 | 0.79 | PDE4B (0.51) | HTR6 | |
| SCHEMBL1012382 | 0.79 | PDE4B (0.51) | HTR6 | |
| SCHEMBL1012384 | 0.79 | PDE4B (0.51) | HTR6 | |
| SCHEMBL1014637 | 0.76 | HTR6 (0.53) | HTR6 | |
| SCHEMBL1015288 | 0.76 | HTR6 (0.53) | HTR6 | |
| SCHEMBL1014636 | 0.76 | HTR6 (0.53) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-B1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-12 | — | — | EP | disclosed |