Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183626 | 0.90 | EGFR (0.40) | DRD2SLC6A4EGFROPRM1OPRL1 | |
| SCHEMBL10183124 | 0.87 | EGFR (0.42) | EGFROPRM1OPRL1LMNAGAA | |
| SCHEMBL10183143 | 0.87 | GAA (0.44) | EGFRLMNAGAAHTTKMT2A | |
| SCHEMBL10183230 | 0.86 | GLRA3 (0.35) | DRD2SLC6A4EGFRUSP2LMNA | |
| SCHEMBL10183137 | 0.86 | GAA (0.46) | EGFROPRM1OPRL1LMNAGAA | |
| SCHEMBL10183630 | 0.84 | EGFR (0.45) | EGFRGAAPRMT5FLT3HSD17B10 | |
| SCHEMBL10183640 | 0.82 | DRD2 (0.43) | DRD2SLC6A4EGFRLMNASMN1; SMN2 | |
| SCHEMBL10183158 | 0.82 | DRD2 (0.43) | DRD2SLC6A4EGFRLMNASMN1; SMN2 | |
| SCHEMBL10235443 | 0.78 | DRD2 (0.46) | DRD2SLC6A4EGFROPRM1OPRL1 | |
| SCHEMBL15943817 | 0.78 | DRD2 (0.46) | DRD2SLC6A4OPRM1OPRL1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | DRD2 4814/4885SLC6A4 4779/4885EGFR 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.