Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183044 | 0.98 | MAPK1 (0.47) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL10183038 | 0.93 | AR (0.44) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL26080794 | 0.77 | MAPK1 (0.40) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL23107314 | 0.76 | MAPK1 (0.58) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL25772014 | 0.76 | MAPK1 (0.58) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL16938257 | 0.76 | MAPK1 (0.58) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL25915799 | 0.75 | MAPK1 (0.43) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3952325 | 0.73 | MAPK1 (0.56) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL950413 | 0.73 | HPGD (0.53) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL23132309 | 0.72 | HPGD (0.50) | MAPK1HPGDHTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | MAPK1 273/4885HPGD 2536/4885HTT 4150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.