Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 5/20 | 0.52 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | ALPG | P10696 | 2/20 | 0.37 |
| ▸ | ALPP | P05187 | 1/20 | 0.37 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183290 | 0.84 | IDH1 (0.50) | IDH1SMN1; SMN2TSHRHRH3LMNA | |
| SCHEMBL10185959 | 0.83 | IDH1 (0.52) | IDH1THRB | |
| SCHEMBL10183302 | 0.83 | PTAFR (0.41) | IDH1PTAFRSMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL10183299 | 0.82 | OPRM1 (0.40) | IDH1MAPTLMNAHTT | |
| SCHEMBL10183680 | 0.81 | IDH1 (0.39) | IDH1 | |
| SCHEMBL10183319 | 0.81 | MEN1 (0.43) | IDH1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL10183337 | 0.81 | OPRM1 (0.39) | IDH1MAPTLMNAHTT | |
| SCHEMBL10184102 | 0.81 | IDH1 (0.37) | IDH1MAPTLMNAPOLB | |
| SCHEMBL10183782 | 0.80 | OPRM1 (0.40) | IDH1MAPTLMNA | |
| SCHEMBL10185644 | 0.80 | IDH1 (0.48) | IDH1THRBMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |