Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 19/20 | 0.72 |
| ▸ | PPARG | P37231 | 13/20 | 0.72 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13906192 | 0.93 | PPARA (0.63) | PPARAPPARGFFAR1 | |
| SCHEMBL10184446 | 0.93 | PPARA (0.71) | PPARAPPARGFFAR1 | |
| Muraglitazar SCHEMBL676469 | 0.84 | PPARA (1.00) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13899411 | 0.83 | PPARA (0.63) | PPARAPPARGFFAR1 | |
| SCHEMBL13722049 | 0.81 | PPARA (0.93) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13718146 | 0.80 | PPARA (0.93) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL5225150 | 0.79 | FFAR1 (0.52) | PPARAPPARGFFAR1 | |
| SCHEMBL10186269 | 0.79 | PPARA (0.75) | PPARAPPARG | |
| SCHEMBL13899606 | 0.79 | PPARA (0.56) | PPARAPPARGFFAR1 | |
| SCHEMBL6073227 | 0.79 | PPARA (0.90) | PPARAPPARGCYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531810-B1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2012-02-01 | — | — | EP | disclosed |