Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183324 | 0.87 | IDH1 (0.37) | IDH1OPRM1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL10185674 | 0.86 | IDH1 (0.48) | LMNAIDH1OPRM1OPRK1OPRL1 | |
| SCHEMBL10183330 | 0.86 | IDH1 (0.48) | LMNAIDH1OPRM1OPRK1OPRL1 | |
| SCHEMBL10184102 | 0.84 | IDH1 (0.37) | LMNAIDH1OPRM1OPRK1OPRL1 | |
| SCHEMBL10183317 | 0.83 | OPRM1 (0.39) | LMNAIDH1L3MBTL1OPRM1OPRK1 | |
| SCHEMBL10185557 | 0.83 | OPRM1 (0.39) | LMNAIDH1L3MBTL1OPRM1OPRK1 | |
| SCHEMBL10183299 | 0.82 | OPRM1 (0.40) | LMNAIDH1OPRM1OPRK1OPRL1 | |
| SCHEMBL10183319 | 0.81 | MEN1 (0.43) | LMNAIDH1OPRM1OPRK1OPRL1 | |
| SCHEMBL10183337 | 0.81 | OPRM1 (0.39) | LMNAIDH1OPRM1OPRK1OPRL1 | |
| SCHEMBL10183782 | 0.81 | OPRM1 (0.40) | LMNAIDH1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |