Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185926 | 0.85 | OPRM1 (0.39) | OPRM1LMNAALDH1A1OPRK1OPRL1 | |
| SCHEMBL10183666 | 0.85 | OPRM1 (0.39) | OPRM1LMNAALDH1A1OPRK1OPRL1 | |
| SCHEMBL10183802 | 0.84 | OPRM1 (0.38) | OPRM1LMNAALDH1A1CHRM2CHRM3 | |
| SCHEMBL10185544 | 0.82 | OPRM1 (0.40) | OPRM1LMNAALDH1A1CHRM2CHRM3 | |
| SCHEMBL10183299 | 0.82 | OPRM1 (0.40) | OPRM1LMNAOPRK1OPRL1TP53 | |
| SCHEMBL10183337 | 0.81 | OPRM1 (0.39) | OPRM1LMNAOPRK1OPRL1TP53 | |
| SCHEMBL10183319 | 0.81 | MEN1 (0.43) | OPRM1LMNAALDH1A1OPRK1OPRL1 | |
| SCHEMBL10183782 | 0.79 | OPRM1 (0.40) | OPRM1LMNAOPRK1OPRL1TP53 | |
| SCHEMBL10183654 | 0.79 | IDH1 (0.38) | OPRM1LMNAOPRK1OPRL1TP53 | |
| SCHEMBL10184015 | 0.79 | OPRM1 (0.37) | OPRM1LMNAALDH1A1HPGDOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |