Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459270 | 0.91 | PIK3CD (0.60) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL460697 | 0.89 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL10187713 | 0.88 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL10187719 | 0.87 | PIK3CD (0.55) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL10187715 | 0.86 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL10187727 | 0.84 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL10187712 | 0.83 | PIK3CD (0.53) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL10187616 | 0.81 | ABL1 (0.36) | PIK3CGPIK3CDPIK3CAPIK3CBTLR8 | |
| SCHEMBL463595 | 0.80 | PIK3CD (0.48) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL470096 | 0.79 | PIK3CD (0.61) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9326987-B2 | Indazole derivatives for use in the treatment of influenza virus infection | GLAXO GROUP LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8524751-B2 | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases | GlaxoSmithKline Intellecutual Property Development (GB) | 2013-09-03 | — | — | US | disclosed |
| US-20130165433-A1 | Novel Use | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-06-27 | — | — | US | disclosed |
| US-20120053166-A1 | 4-Oxadiazol-2-YL-Indazoles as Inhibitors of P13 Kinases | GLAXO GROUP LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165433-A1 | Novel Use | HAVCR2, MAVS, ENTPD5 | PIK3CG 2718/4885PIK3CD 2938/4885PIK3CA 2691/4885 |
| US-20120053166-A1 | 4-Oxadiazol-2-YL-Indazoles as Inhibitors of P13 Kinases | CDK3, CDK13, AKT3 | PIK3CG 33/4885PIK3CD 11/4885PIK3CA 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.