Sugi Predict

Sugi Predict / Targets / MAVS

MAVS

Mitochondrial antiviral-signaling protein · Q7Z434 · MAVS on Sugi Atlas →

0 patent compounds predicted against MAVS, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to MAVS by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Prevent Cardiac Surgery Associated AKI Trial PHASE2RECRUITING
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19 PHASE2UNKNOWN
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial PHASE1/PHASE2COMPLETED
Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety. PHASE1/PHASE2UNKNOWN
Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder PHASE2WITHDRAWN
Phase I Study of the Safety, Tolerability, and Efficacy of an Engineered Mitochondrial Vaccine in Advanced Solid Tumors PHASE1RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
ADAR1 Expression Level in Rectal Cancer nanRECRUITING
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches nanUNKNOWN
Mitochondrial Dysfunction Contributes to Sepsis Induced Cardiac Dysfunction nanWITHDRAWN
Environmental Pollutants in COPD and Lung Cancer nanRECRUITING
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis nanRECRUITING
Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage nanCOMPLETED
Expression of Inflammatory Markers in the Course of Acute Respiratory Viral Infections nanNOT_YET_RECRUITING
Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency nanWITHDRAWN
Immune Responses With Reduxium nanCOMPLETED
Immunological Profiling of Patients With COVID-19 in Respiratory Distress nanCOMPLETED
mtDNA as Novel Biomarker for Intra-amniotic Infection nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis nanUNKNOWN
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery nanWITHDRAWN
Characterization of the IFN-I Response in Subjects Who Experienced Severe or Mild Forms of COVID-19 nanRECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING
Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MAVS binder may also engage these)

ProteinNameSimilarity
Q66HG9 — 0.996 Q66HG9 →
Q8N1P7 — 0.992 Q8N1P7 →
Q6NXZ1 — 0.992 Q6NXZ1 →
Q7TSA6 — 0.990 Q7TSA6 →
Q8VCF0 — 0.990 Q8VCF0 →
Q0GGX2 — 0.990 Q0GGX2 →
Q6DIA7 — 0.990 Q6DIA7 →
E9Q394 — 0.989 E9Q394 →
Q5VV67 — 0.989 Q5VV67 →
Q8BHE4 — 0.989 Q8BHE4 →
Q5DTX6 — 0.989 Q5DTX6 →
E9Q286 — 0.989 E9Q286 →
Q8BWS5 — 0.989 Q8BWS5 →
B7ZNG4 — 0.988 B7ZNG4 →
A6QLF8 — 0.988 A6QLF8 →
Q96L96 — 0.988 Q96L96 →
Q12815 — 0.988 Q12815 →
Q8N944 — 0.988 Q8N944 →
Q6NS69 — 0.987 Q6NS69 →
Q4R736 — 0.987 Q4R736 →
A6NFR6 — 0.987 A6NFR6 →
Q924C5 — 0.987 Q924C5 →
Q71M36 — 0.987 Q71M36 →
Q3UIZ8 — 0.987 Q3UIZ8 →
Q5RCQ2 — 0.986 Q5RCQ2 →
D3ZUE1 — 0.986 D3ZUE1 →
Q5SWP3 — 0.986 Q5SWP3 →
Q8BHP2 — 0.986 Q8BHP2 →
Q6PAC4 — 0.986 Q6PAC4 →
A8MYA2 — 0.986 A8MYA2 →