Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456900 | 0.92 | PIK3CA (0.51) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL10187727 | 0.89 | PIK3CD (0.49) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL10187720 | 0.86 | PIK3CD (0.48) | PIK3C3PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10187622 | 0.85 | PIK3C3 (0.39) | PIK3C3PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10187718 | 0.85 | PIK3CA (0.44) | PIK3C3PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL470449 | 0.81 | PIK3CD (0.61) | PIK3C3PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL470140 | 0.79 | PIK3CA (0.66) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL456861 | 0.78 | PIK3CA (0.46) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL459638 | 0.78 | PIK3CA (0.59) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL10187726 | 0.78 | PIK3CA (0.43) | PIK3C3PIK3CAPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9326987-B2 | Indazole derivatives for use in the treatment of influenza virus infection | GLAXO GROUP LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8524751-B2 | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases | GlaxoSmithKline Intellecutual Property Development (GB) | 2013-09-03 | — | — | US | disclosed |
| US-20130165433-A1 | Novel Use | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-06-27 | — | — | US | disclosed |
| US-20120053166-A1 | 4-Oxadiazol-2-YL-Indazoles as Inhibitors of P13 Kinases | GLAXO GROUP LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165433-A1 | Novel Use | HAVCR2, MAVS, ENTPD5 | PIK3C3 4369/4885PIK3CA 2691/4885PIK3R1 3030/4885 |
| US-20120053166-A1 | 4-Oxadiazol-2-YL-Indazoles as Inhibitors of P13 Kinases | CDK3, CDK13, AKT3 | PIK3C3 7/4885PIK3CA 6/4885PIK3R1 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.