Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15688949 | 0.88 | HRH4 (0.51) | MAPK1HRH4MKNK2RETCTSK | |
| SCHEMBL10187331 | 0.85 | CTSK (0.58) | HRH4MKNK2RETPLK4CTSK | |
| SCHEMBL8303185 | 0.81 | HRH3 (0.59) | MAPK1HRH4MKNK1MKNK2PLK4 | |
| SCHEMBL15830033 | 0.81 | MAPK1 (0.62) | MAPK1HRH4MKNK1MKNK2RET | |
| SCHEMBL29499534 | 0.79 | MAPK1 (0.55) | MAPK1HRH4MKNK1MKNK2RET | |
| SCHEMBL16220909 | 0.78 | MAPK1 (0.58) | MAPK1HRH4MKNK1MKNK2RET | |
| SCHEMBL14004978 | 0.77 | MAPK1 (0.57) | MAPK1HRH4MKNK1MKNK2RET | |
| SCHEMBL19171094 | 0.77 | MAPK1 (0.57) | MAPK1HRH4MKNK1MKNK2RET | |
| SCHEMBL2568620 | 0.77 | MAPK1 (1.00) | MAPK1HRH4MKNK1MKNK2RET | |
| SCHEMBL28941129 | 0.77 | MAPK1 (0.49) | MAPK1HRH4MKNK1MKNK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012001107-A1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |