CTSK — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL150073	0.51	18/20
SCHEMBL18535	0.60	16/20
SCHEMBL56438	0.50	15/20
SCHEMBL73696	0.53	14/20
SCHEMBL73697	0.53	14/20
SCHEMBL75827	0.53	14/20
SCHEMBL86153	0.56	13/20
SCHEMBL86185	0.56	13/20
SCHEMBL165350	0.47	13/20
SCHEMBL165351	0.47	13/20
Water (SCHEMBL44988)	0.56	12/20
SCHEMBL160926	0.55	12/20
SCHEMBL84426	0.53	12/20
SCHEMBL17393	0.51	12/20
SCHEMBL86237	0.44	12/20
SCHEMBL86310	0.44	12/20
SCHEMBL166957	0.42	12/20
SCHEMBL67061	0.66	11/20
SCHEMBL10652	0.53	11/20
SCHEMBL142265	0.52	11/20

Clinical trials — most relevant to CTSK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Impact of Pcsk-9 Inhibition on PET CFR in Patients at High CV Risk	PHASE4	RECRUITING
Ulinastatin in Severe Acute Pancreatitis	PHASE4	SUSPENDED
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19	PHASE2/PHASE3	UNKNOWN
STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19	PHASE3	COMPLETED
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients	PHASE3	RECRUITING
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration	PHASE2	UNKNOWN
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Evaluation of the Changes in Matrix Metalloproteinase-9 Levels With Salvadora Persica (Miswak) in Periodontal Fibroblasts and Gingival Crevicular Fluid in Patients With Periodontitis	EARLY_PHASE1	NOT_YET_RECRUITING
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Long Term Outcome of Congenital Solitary Kidney	nan	UNKNOWN
Synovial Fluid Bank From Arthritic Patients	nan	RECRUITING
The Benefit of Оn-Line High Convection Volume Hemodiafiltration Treatment Versus High Flow Dialysis on Reduction of Oxidative Stress and Health Related Quality of Life in Dialysis Patients	nan	COMPLETED
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD	nan	NOT_YET_RECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
Salivary Biomarkers for Sjögren's Syndrome Detection	nan	COMPLETED
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer	nan	UNKNOWN
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery	nan	RECRUITING
A Cohort Study of Correlation Between Mast Cells and Prognosis in Patients With Acute Myocardial Infarction	nan	UNKNOWN
Biomarkers of Acute Kidney Injury Following Cardiac Surgery	nan	UNKNOWN
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery	nan	ENROLLING_BY_INVITATION
Assessment and Monitoring of Renal Proximal Tubular Tolerance of Nucleoside and Nucleotide Analogues Using Early Screening Tools in Patients Chronically Mono-infected With Hepatitis B Virus	nan	COMPLETED
Magnetic Nanoparticles System in Acute Coronary Syndrome	nan	COMPLETED
Proteases in Patients With Prostate Cancer That Has Spread to the Bone	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CTSK binder may also engage these)

Protein	Name	Similarity
Q5E968	—	1.000	Q5E968 →
Q3ZKN1	—	1.000	Q3ZKN1 →
P61276	—	1.000	P61276 →
Q9GLE3	—	0.999	Q9GLE3 →
P61277	—	0.999	P61277 →
P55097	—	0.998	P55097 →
P43236	—	0.998	P43236 →
O35186	—	0.996	O35186 →
P06797	—	0.995	P06797 →
CTSV	Cathepsin L2	0.994	landscape →
CTSS	Cathepsin S	0.994	landscape →
Q9JI81	—	0.992	Q9JI81 →
P25326	—	0.991	P25326 →
Q80UB0	—	0.991	Q80UB0 →
O70370	—	0.990	O70370 →
P25975	—	0.990	P25975 →
Q91ZF2	—	0.989	Q91ZF2 →
Q9QZE3	—	0.989	Q9QZE3 →
O45734	—	0.989	O45734 →
Q9GKL8	—	0.989	Q9GKL8 →
Q9JIA9	—	0.989	Q9JIA9 →
Q5E998	—	0.989	Q5E998 →
P25773	—	0.989	P25773 →
Q63088	—	0.989	Q63088 →
P15242	—	0.988	P15242 →
CTSH	Pro-cathepsin H	0.988	landscape →
P49935	—	0.988	P49935 →
Q8HY82	—	0.988	Q8HY82 →
Q9GL24	—	0.988	Q9GL24 →
Q8HY81	—	0.987	Q8HY81 →