SCHEMBL10189285

SCHEMBL10189285

O=C(NC[C@H]1CN(c2cc(F)c(N3CCNN(C(=O)NCc4nccs4)CC3)c(F)c2)C(=O)O1)C(F)F

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.38
MAOB P27338 5/20 0.38
MAOA P21397 6/20 0.37
LMNA P02545 1/20 0.36
PTGS1 P23219 1/20 0.36
CALML3 P27482 1/20 0.36
SDHA P31040 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13589024 0.94 F10 (0.38) F10MAOBMAOALMNAPTGS1
SCHEMBL10151609 0.92 F10 (0.40) F10MAOBMAOALMNAPTGS1
SCHEMBL10189286 0.91 MAOA (0.46) F10MAOBMAOALMNAPTGS1
SCHEMBL10151816 0.91 F10 (0.49) F10MAOBMAOALMNAPTGS1
SCHEMBL10152081 0.91 F10 (0.39) F10MAOBMAOALMNAPTGS1
SCHEMBL13589023 0.90 MAOA (0.42) F10MAOBMAOALMNAPTGS1
SCHEMBL13357938 0.89 MAOA (0.39) F10MAOBMAOALMNAPTGS1
SCHEMBL10152642 0.89 MAOB (0.42) F10MAOBMAOALMNAPTGS1
SCHEMBL10152067 0.87 F10 (0.39) F10MAOBMAOALMNAPTGS1
SCHEMBL13357891 0.85 F10 (0.39) F10MAOBMAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2009012-B1 NOVEL COMPOUND HAVING HETEROCYCLIC RING RES FOUND ITSUU LAB (JP) 2014-06-25 EP disclosed
US-20120208997-A1 NOVEL COMPOUND HAVING HETEROCYCLIC RING SUZUKI HIDEYUKI (JP) 2012-08-16 US disclosed
US-8148362-B2 Compound having heterocyclic ring RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2012-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120208997-A1 NOVEL COMPOUND HAVING HETEROCYCLIC RING OXA1L, MRPL21, TOP1 F10 1264/4885MAOB 1404/4885MAOA 1563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.