MAOA

Amine oxidase [flavin-containing] A · P21397 · MAOA on Sugi Atlas →

639,115 patent compounds predicted against MAOA, 364,325 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL8513 SCHEMBL8513 0.71 18/20
SCHEMBL27895 SCHEMBL27895 0.67 14/20
Cilostazol Cilostazol (SCHEMBL16128) 0.50 10/20
SCHEMBL21409 SCHEMBL21409 0.61 9/20
Selegiline Selegiline (SCHEMBL22232) 1.00 8/20
Linezolid Linezolid (SCHEMBL5027) 1.00 7/20
Athraquinones A Athraquinones A (SCHEMBL18614) 1.00 7/20
SCHEMBL22284 SCHEMBL22284 1.00 7/20
SCHEMBL13323 SCHEMBL13323 0.59 7/20
SCHEMBL8751 SCHEMBL8751 0.51 7/20
SCHEMBL13777 SCHEMBL13777 0.43 7/20
SCHEMBL13778 SCHEMBL13778 0.43 7/20
Psoralen Psoralen (SCHEMBL17835) 1.00 6/20
Daidzein Daidzein (SCHEMBL19814) 1.00 6/20
SCHEMBL21408 SCHEMBL21408 0.58 6/20
Anthralin Anthralin (SCHEMBL3197) 0.56 6/20
SCHEMBL8557 SCHEMBL8557 0.55 6/20
SCHEMBL14958 SCHEMBL14958 0.52 6/20
SCHEMBL15851 SCHEMBL15851 0.52 6/20
Anthraquinone Anthraquinone (SCHEMBL14943) 0.79 5/20

Clinical trials — most relevant to MAOA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparative Evaluation of Handling Characteristics of Two Adrenaline Autoinjectors,EpiPen in Comparison With Jext PHASE4COMPLETED
Early Versus Delayed Switch in Medication in Patients With Major Depressive Disorder PHASE4COMPLETED
Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) PHASE4UNKNOWN
Study of Urate Elevation in Parkinson's Disease, Phase 3 PHASE3COMPLETED
Open Pilot Trial of BHV-4157 PHASE3ACTIVE_NOT_RECRUITING
Clinical Trial of Anusol Ointment for Symptom Relief in Patients With Haemorrhoids PHASE3COMPLETED
Efficacy of TCM Capsules Lian Hua Qing Wen Jiao Nang in Mild COVID-19 Patients PHASE2/PHASE3COMPLETED
Duloxetine in the Treatment of Melancholic Depression PHASE3COMPLETED
Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans PHASE2NOT_YET_RECRUITING
Two Dose Levels of DFN-15 vs. Placebo in Patients With Migraine Headaches PHASE2COMPLETED
Study of AD128 Versus Placebo in Obstructive Sleep Apnea PHASE2COMPLETED
A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM) PHASE2COMPLETED
Dose-Finding Study of NBX-100 in Healthy Adult Participants PHASE1NOT_YET_RECRUITING
GZ17-6.02 in Advanced CRPC After Progression on Anti-Androgen Therapy PHASE1RECRUITING
Study Assessing the Safety and Therapeutic Effect of Buprenorphine in MDD Patients PHASE1UNKNOWN
Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study EARLY_PHASE1SUSPENDED
A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A) EARLY_PHASE1COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke nanCOMPLETED
Pretreatment Identification of Duloxetine Success in Neuropathic Pain Patients nanCOMPLETED
Bupropion in the Treatment of Methamphetamine Dependence nanCOMPLETED
Effects of Methylphenidate on Brain and Cognition in 22q11 Deletion Syndrome nanCOMPLETED
MAO-B Occupancy in Depressed Patients nanCOMPLETED
Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression nanCOMPLETED
Adult Outcome of Children With Attention-deficit/Hyperactivity Disorder nanCOMPLETED
Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET nanCOMPLETED
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET nanCOMPLETED
Serotonergic System and Violent Video Games nanCOMPLETED
Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fed Conditions nanCOMPLETED
The Effects of Dextroamphetamine on Brain Function nanCOMPLETED
Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fasting Conditions nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MAOA binder may also engage these)

ProteinNameSimilarity
Q5RE60 1.000 Q5RE60 →
P21398 1.000 P21398 →
Q6Q2J0 1.000 Q6Q2J0 →
P21396 1.000 P21396 →
Q64133 1.000 Q64133 →
Q5NU32 1.000 Q5NU32 →
Q6NSN2 1.000 Q6NSN2 →
P58027 1.000 P58027 →
Q7YRB7 1.000 Q7YRB7 →
Q5RE98 1.000 Q5RE98 →
P19643 1.000 P19643 →
MAOB Amine oxidase [flavin-containing] B 1.000 landscape →
P56560 1.000 P56560 →
Q8BW75 1.000 Q8BW75 →
P49253 1.000 P49253 →
P58028 1.000 P58028 →
Q6PLK3 0.997 Q6PLK3 →
Q6TGQ8 0.993 Q6TGQ8 →
P0CC17 0.991 P0CC17 →
Q0J954 0.991 Q0J954 →
Q4JHE2 0.989 Q4JHE2 →
Q9FNA2 0.989 Q9FNA2 →
Q90W54 0.989 Q90W54 →
B5AR80 0.988 B5AR80 →
Q8H191 0.988 Q8H191 →
A8QL58 0.987 A8QL58 →
Q54IT3 0.987 Q54IT3 →
P81383 0.987 P81383 →
Q7XR46 0.986 Q7XR46 →
Q556K4 0.986 Q556K4 →