Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015141 | 0.86 | PAK4 (0.59) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL1018622 | 0.86 | TTK (0.52) | TTKJAK3BTKEGFRMAP3K7 | |
| SCHEMBL1016206 | 0.86 | TTK (0.49) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL1016309 | 0.85 | TTK (0.51) | TTKJAK3BTKEGFRMAP3K7 | |
| SCHEMBL1018567 | 0.84 | PTK2 (0.50) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL1074127 | 0.84 | PTK2 (0.50) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL4383660 | 0.84 | JAK3 (0.52) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL4383672 | 0.84 | JAK3 (0.52) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL27912557 | 0.83 | JAK3 (0.50) | TTKJAK3BTKEGFRJAK1 | |
| SCHEMBL1019052 | 0.78 | TTK (0.47) | TTKJAK3BTKEGFRJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |