Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 11/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018622 | 0.99 | TTK (0.52) | TTKJAK3BTKPTK2MAP3K7 | |
| SCHEMBL1015141 | 0.88 | PAK4 (0.59) | TTKJAK3BTKEGFR | |
| SCHEMBL1016206 | 0.87 | TTK (0.49) | TTKJAK3BTKPTK2MAP3K7 | |
| SCHEMBL1018943 | 0.85 | TTK (0.47) | TTKJAK3BTKMAP3K7EGFR | |
| SCHEMBL1019052 | 0.82 | TTK (0.47) | TTKJAK3BTKPTK2MAP3K7 | |
| SCHEMBL2021311 | 0.82 | TTK (0.67) | TTKJAK3BTKPTK2KDM4E | |
| SCHEMBL1018447 | 0.82 | PTK2 (0.55) | TTKJAK3BTKPTK2KDM4E | |
| SCHEMBL1017585 | 0.81 | JAK3 (0.54) | TTKJAK3BTKMAP3K7EGFR | |
| SCHEMBL1017917 | 0.81 | PTK2 (0.56) | TTKJAK3BTKPTK2KDM4E | |
| SCHEMBL1018711 | 0.81 | TTK (0.46) | TTKJAK3BTKPTK2MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |