Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195043 | 0.91 | BACE1 (0.49) | ACKR3BACE1ALDH1A1POLBMEN1 | |
| SCHEMBL10194903 | 0.89 | BACE1 (0.45) | ACKR3BACE1ALDH1A1POLBMEN1 | |
| SCHEMBL10193692 | 0.86 | ACKR3 (0.44) | ACKR3BACE1ALDH1A1POLBMEN1 | |
| SCHEMBL10192948 | 0.85 | BACE1 (0.51) | BACE1 | |
| SCHEMBL10193690 | 0.85 | ACKR3 (0.44) | ACKR3BACE1ALDH1A1POLBMEN1 | |
| SCHEMBL10194912 | 0.81 | PRSS1 (0.46) | ACKR3BACE1ALDH1A1POLBMEN1 | |
| SCHEMBL10193576 | 0.81 | NPC1 (0.43) | BACE1SMN1; SMN2 | |
| SCHEMBL10193143 | 0.78 | BACE1 (0.47) | BACE1 | |
| SCHEMBL10193709 | 0.77 | SMN1; SMN2 (0.42) | ACKR3BACE1ALDH1A1POLBMEN1 | |
| SCHEMBL10194093 | 0.77 | BACE1 (0.42) | ACKR3BACE1ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415756-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |