Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | CBLB | Q13191 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194093 | 0.88 | BACE1 (0.42) | SMN1; SMN2AURKAALDH1A1POLBMEN1 | |
| SCHEMBL10193694 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL10195044 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2AURKAALDH1A1POLBMEN1 | |
| SCHEMBL10193021 | 0.86 | BACE1 (0.48) | AURKAGRM4BACE1RPS6KB1 | |
| SCHEMBL10193712 | 0.85 | AURKA (0.57) | AURKABACE1RPS6KB1 | |
| SCHEMBL10193565 | 0.82 | ALDH1A1 (0.39) | SMN1; SMN2AURKAALDH1A1POLBMEN1 | |
| SCHEMBL10194892 | 0.82 | AURKA (0.43) | SMN1; SMN2AURKAALDH1A1MEN1KMT2A | |
| SCHEMBL10194102 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2GRM4BACE1 | |
| SCHEMBL10194912 | 0.80 | PRSS1 (0.46) | SMN1; SMN2ALDH1A1POLBMEN1LMNA | |
| SCHEMBL10193160 | 0.78 | BACE1 (0.48) | SMN1; SMN2ALDH1A1POLBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415756-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |