Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 7/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 9/20 | 0.54 |
| ▸ | HRH1 | P35367 | 7/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194126 | 0.94 | MEN1 (0.64) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL5946392 | 0.88 | MEN1 (0.81) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL10194132 | 0.87 | MEN1 (0.63) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL10194053 | 0.86 | HTR2C (0.67) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL10194052 | 0.85 | HTR2C (0.79) | HTR2CHTR2AHRH1DRD2DRD1 | |
| SCHEMBL5946345 | 0.82 | MEN1 (0.79) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL10194134 | 0.82 | MEN1 (0.61) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL5946369 | 0.81 | MEN1 (0.77) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| SCHEMBL5946376 | 0.81 | MEN1 (0.76) | MEN1ABCB11LMNACYP1A2CYP3A4 | |
| Loxapine SCHEMBL5500954 | 0.80 | LMNA (1.00) | MEN1ABCB11LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101596-B2 | Loxapine analogs and methods of use thereof | HYPNION INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101596-B2 | Loxapine analogs and methods of use thereof | HYPNION INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-7592333-B2 | Loxapine analogs and methods of use thereof | HYPNION, INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592333-B2 | Loxapine analogs and methods of use thereof | HYPNION, INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-20090186872-A1 | LOXAPINE ANALOGS AND METHODS OF USE THEREOF | EDGAR DALE M | 2009-07-23 | — | — | US | disclosed |
| US-20090186872-A1 | LOXAPINE ANALOGS AND METHODS OF USE THEREOF | EDGAR DALE M | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186872-A1 | LOXAPINE ANALOGS AND METHODS OF USE THEREOF | HCRTR2, HCRTR1, HTR3B | MEN1 4531/4885ABCB11 4824/4885LMNA 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.