SCHEMBL10194347

SCHEMBL10194347

Cc1nc(N=Nc2c(C)nn(-c3nc(-n4nc(C)c(N=Nc5nc(C)nn5-c5ccccc5)c4N)[nH]c(=O)n3)c2N)n(-c2ccccc2)n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 11/20 0.51
MAPT P10636 10/20 0.51
RAB9A P51151 10/20 0.51
NPC1 O15118 9/20 0.51
TDP1 Q9NUW8 6/20 0.51
HPGD P15428 6/20 0.51
ALDH1A1 P00352 2/20 0.51
MAPK1 P28482 5/20 0.47
KMT2A Q03164 3/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
HTT P42858 3/20 0.47
MEN1 O00255 2/20 0.47
ALOX12 P18054 1/20 0.47
LMNA P02545 4/20 0.43
NFKB1 P19838 3/20 0.39
NFKB2 Q00653 3/20 0.39
RELA Q04206 3/20 0.39
PLA2G1B P04054 1/20 0.37
ATG4B Q9Y4P1 1/20 0.37
GAA P10253 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10194355 0.88 MAPT (0.55) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL10194352 0.87 MAPT (0.51) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL10194349 0.81 SMN1; SMN2 (0.57) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL824849 0.81 MAPT (0.60) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL824621 0.78 SMN1; SMN2 (0.64) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL824587 0.77 MAPT (0.51) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL824569 0.76 MAPT (0.52) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL10194351 0.74 MAPT (0.55) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL10194253 0.74 NPC1 (0.33) SMN1; SMN2MAPTRAB9ANPC1TDP1
SCHEMBL10194295 0.74 SMN1; SMN2 (0.38) SMN1; SMN2MAPTRAB9ANPC1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8118885-B2 Azo pigments, process for producing the azo pigments, and pigment dispersion, coloring composition and ink for inkjet recording containing the pigment FUJIFILM CORPORATION (JP) 2012-02-21 US disclosed
US-20110030583-A1 AZO PIGMENTS, PROCESS FOR PRODUCING THE AZO PIGMENTS, AND PIGMENT DISPERSION, COLORING COMPOSITION AND INK FOR INKJET RECORDING CONTAINING THE PIGMENT FUJIFILM COPORATION (JP) 2011-02-10 US disclosed