Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 15/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1070941 | 0.87 | ULK1 (0.53) | ULK1SYKPTK2PTK2BCDK1 | |
| SCHEMBL4305668 | 0.86 | ULK1 (0.55) | ULK1SYKPTK2PTK2B | |
| SCHEMBL4305660 | 0.85 | ULK1 (0.51) | ULK1SYKPTK2PTK2BJAK2 | |
| SCHEMBL1015170 | 0.83 | ULK1 (0.53) | ULK1SYKPTK2PTK2BCDK1 | |
| SCHEMBL1017516 | 0.82 | ULK1 (0.51) | ULK1SYKPTK2PTK2BJAK2 | |
| SCHEMBL1019485 | 0.81 | ULK1 (0.52) | ULK1SYKPTK2PTK2BJAK2 | |
| SCHEMBL1018051 | 0.81 | JAK3 (0.52) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL12085355 | 0.79 | ULK1 (0.50) | ULK1SYKPTK2PTK2BCDK1 | |
| SCHEMBL1017838 | 0.79 | SYK (0.43) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1071647 | 0.78 | ULK1 (0.55) | ULK1SYKPTK2PTK2BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |