Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194891 | 0.91 | MAPK10 (0.42) | MAPK10CHEK1CDK7JAK2HPGD | |
| SCHEMBL10194789 | 0.90 | MAPK10 (0.47) | MAPK10CHEK1CDK7JAK2HPGD | |
| SCHEMBL10194799 | 0.89 | MAPK10 (0.47) | MAPK10CHEK1CDK7JAK2FLT3 | |
| SCHEMBL10195370 | 0.88 | MAPK10 (0.46) | MAPK10CHEK1CDK7JAK2FLT3 | |
| SCHEMBL10196821 | 0.88 | JAK2 (0.46) | MAPK10CHEK1JAK2HPGDSMN1; SMN2 | |
| SCHEMBL10194879 | 0.87 | RAB9A (0.46) | MAPK10JAK2HPGDSMN1; SMN2FLT3 | |
| SCHEMBL10194783 | 0.87 | MAPK10 (0.45) | MAPK10CHEK1CDK7JAK2FLT3 | |
| SCHEMBL10196824 | 0.86 | KIT (0.45) | FLT3RAB9ALRRK2 | |
| SCHEMBL10194705 | 0.86 | JAK2 (0.45) | MAPK10CHEK1JAK2HPGDSMN1; SMN2 | |
| SCHEMBL10194805 | 0.86 | MAPK10 (0.44) | MAPK10CHEK1CDK7JAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |