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Sugi Predict / Compounds / SCHEMBL10194965

SCHEMBL10194965

SCHEMBL10194965

COCCC1CCCN(C(=O)c2ccc(-n3cc(-c4n[nH]c5ccccc45)nn3)cc2)C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FLT3 P36888 3/20 0.41
▸ POLB P06746 2/20 0.41
▸ KMT2A Q03164 3/20 0.39
▸ MAPK8 P45983 2/20 0.39
▸ MAPK10 P53779 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ TP53 P04637 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ PKM P14618 1/20 0.37
▸ GRM3 Q14832 3/20 0.37
▸ AKR1C3 P42330 2/20 0.37
▸ KDM6B O15054 2/20 0.37
▸ KDM2A Q9Y2K7 2/20 0.37
▸ KDM4A O75164 1/20 0.37
▸ KDM5C P41229 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10195583 0.93 KMT2A (0.46) FLT3POLBKMT2AMAPK8MAPK10
SCHEMBL10194857 0.89 FLT3 (0.41) FLT3POLBKMT2AMAPK8MAPK10
SCHEMBL10194775 0.89 FLT3 (0.44) FLT3MAPK8MAPK10ALDH1A1KDM4E
SCHEMBL9951824 0.87 FLT3 (0.42) FLT3MAPK8MAPK10ALDH1A1KDM4E
SCHEMBL10195384 0.87 MAPK10 (0.40) FLT3MAPK8MAPK10ALDH1A1KDM4E
SCHEMBL10194766 0.86 MAPK10 (0.42) FLT3MAPK8MAPK10ALDH1A1KDM4E
SCHEMBL10194699 0.86 FLT3 (0.39) FLT3MAPK8MAPK10ALDH1A1
SCHEMBL9953312 0.84 MAPK10 (0.42) FLT3MAPK8MAPK10ALDH1A1KDM4E
SCHEMBL9952332 0.84 MAPK10 (0.42) FLT3MAPK8MAPK10ALDH1A1KDM4E
SCHEMBL9953616 0.84 MAPK10 (0.42) FLT3MAPK8MAPK10ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655357-B1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO SA (CH) 2016-06-22 — — EP disclosed
EP-2655357-B1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO SA (CH) 2016-06-22 — — EP disclosed
CN-103429585-B Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors MERCK SERONO SA 2015-07-08 — — CN disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
WO-2012084704-A1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO S.A. (CH) 2012-06-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES NFATC1, IL5, CD4 FLT3 282/4885POLB 2810/4885KMT2A 3615/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.