Sugi Predict

Sugi Predict / Compounds / SCHEMBL10195384

SCHEMBL10195384

SCHEMBL10195384

COC1CCCN(C(=O)c2ccc(-n3cc(-c4n[nH]c5ccccc45)nn3)cc2)C1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK10 P53779 3/20 0.40
▸ MAPK8 P45983 2/20 0.40
▸ FLT3 P36888 2/20 0.40
▸ KDM2A Q9Y2K7 3/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ RAB9A P51151 3/20 0.40
▸ NPC1 O15118 2/20 0.40
▸ KDM6B O15054 2/20 0.40
▸ KDM4A O75164 2/20 0.40
▸ KDM5C P41229 2/20 0.40
▸ KDM4C Q9H3R0 2/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ TP53 P04637 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ KDM3A Q9Y4C1 1/20 0.40
▸ HSP90AA1 P07900 1/20 0.39
▸ HSP90AB1 P08238 1/20 0.39
▸ LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10194974 0.89 IDO1 (0.45) MAPK10MAPK8FLT3ALDH1A1LMNA
SCHEMBL10195583 0.89 KMT2A (0.46) MAPK10MAPK8FLT3ALDH1A1RAB9A
SCHEMBL9953312 0.89 MAPK10 (0.42) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL9952332 0.89 MAPK10 (0.42) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL9953616 0.89 MAPK10 (0.42) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL10194965 0.87 FLT3 (0.41) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL10194857 0.87 FLT3 (0.41) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL10194901 0.86 L3MBTL1 (0.46) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL10194775 0.86 FLT3 (0.44) MAPK10MAPK8FLT3KDM2AALDH1A1
SCHEMBL10194782 0.86 MAPK10 (0.53) MAPK10MAPK8FLT3ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655357-B1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO SA (CH) 2016-06-22 — — EP disclosed
EP-2655357-B1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO SA (CH) 2016-06-22 — — EP disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-9073892-B2 Indazolyl triazol derivatives MERCK SERONO S.A. (CH) 2015-07-07 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) 2013-10-17 — — US disclosed
WO-2012084704-A1 INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS MERCK SERONO S.A. (CH) 2012-06-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130274241-A1 INDAZOLYL TRIAZOL DERIVATIVES NFATC1, IL5, CD4 MAPK10 1774/4885MAPK8 1091/4885FLT3 282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.