Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23612575 | 1.00 | TDP1 (0.46) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19325256 | 1.00 | TDP1 (0.46) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10016076 | 1.00 | TDP1 (0.46) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL24120969 | 1.00 | TDP1 (0.46) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14495731 | 1.00 | TDP1 (0.46) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17365287 | 0.91 | POLB (0.62) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22062079 | 0.91 | POLB (0.62) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL819098 | 0.91 | POLB (0.62) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20434234 | 0.91 | POLB (0.39) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15372529 | 0.89 | POLB (0.38) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016569-A1 | DEUTERATED TANDOSPIRONE DERIVATIVES AS 5-HT1A RECEPTOR AGONISTS | CONRIG PHARMA APS (DK) | 2012-02-09 | — | — | WO | disclosed |