Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3315978 | 0.83 | PDE4B (0.59) | NAMPTMAPTTP53THRBKDM4E | |
| SCHEMBL12478772 | 0.83 | NAMPT (0.53) | NAMPTMAPTTHRBKDM4EPTPN2 | |
| SCHEMBL22860327 | 0.78 | PTPN2 (0.49) | MAPTPTPN2PTPN1PTPN6NPC1 | |
| SCHEMBL2830416 | 0.75 | NAMPT (0.59) | NAMPTMAPTKDM4EPTPN2PTPN1 | |
| SCHEMBL18535060 | 0.75 | RXFP1 (0.42) | MAPTNPC1RAB9AKMT2APOLB | |
| SCHEMBL10194877 | 0.75 | HPGD (0.44) | MAPTTP53KMT2APOLBMEN1 | |
| SCHEMBL12479659 | 0.74 | PDE4B (0.51) | NAMPTPDE4B | |
| SCHEMBL12479648 | 0.74 | USP30 (0.44) | NAMPTPDE4BDDB1CRBNNPC1 | |
| SCHEMBL29181014 | 0.74 | NAMPT (0.52) | NAMPTMAPTTP53THRBKDM4E | |
| SCHEMBL30736670 | 0.74 | EPHX2 (0.49) | NAMPTMAPTTHRBKDM4EPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |