Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317800 | 0.88 | KMT2A (0.59) | KMT2AGRM3ALDH1A1MEN1 | |
| SCHEMBL10195711 | 0.82 | KDM2B (0.53) | KMT2APKMGRM3ALDH1A1MEN1 | |
| SCHEMBL10194851 | 0.80 | GRM3 (0.65) | KMT2APKMGRM3ALDH1A1MEN1 | |
| SCHEMBL10195742 | 0.78 | ALDH1A1 (0.54) | KMT2AGRM3ALDH1A1MEN1L3MBTL1 | |
| SCHEMBL10194852 | 0.77 | KMT2A (0.51) | KMT2APKMGRM3ALDH1A1MEN1 | |
| SCHEMBL10196674 | 0.75 | CYP19A1 (0.50) | KMT2APROKR1 | |
| SCHEMBL10195593 | 0.75 | KMT2A (0.52) | KMT2AGRM3PROKR1 | |
| SCHEMBL17888441 | 0.75 | KMT2A (0.54) | KMT2APKMGRM3ALDH1A1MEN1 | |
| SCHEMBL10194849 | 0.75 | GRM3 (0.53) | KMT2AGRM3ALDH1A1MEN1PROKR1 | |
| SCHEMBL3456176 | 0.73 | RECQL (0.73) | KMT2APKMALDH1A1MEN1PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |